David Tai Leong, Ph.D.
David Tai Leong, Ph.D.
Associate Professor
Department of Chemical and Biomolecular Engineering
National University of Singapore
4 Engineering Drive 4, E5-02-18, Singapore 117585, Singapore
Tel: +65-6516-7262
Email: cheltwd@nus.edu.sg
David Leong is a tenured Associate Professor at the Department of Chemical and Biomolecular Engineering, National University of Singapore. He received his B Chemical Engineering and PhD in biology degrees from National University of Singapore, working on bone tissue engineering with adipose derived stem cells. He did his postdoctoral studies in Howard Hughes Medical Institute, University of Pennsylvania Medical School, working on diabetes and metabolism biological mechanisms. He returned to Singapore to his first independent position as a Lee Kuan Yew Fellow in the Cancer Science Institute, National University of Singapore with a focus on cancer biology. Subsequently, he returned to his alma mater department and was promoted to his current tenured position in 2017. His research interests range from chemical synthesis to biological mechanisms of nanomaterials-biology interactions especially nanoparticles with the endothelium; working with a wide range of materials and constructs, from noble metals nanoclusters to commonly found inorganic nanoparticles to semiconductive transition metals dichalogenides to DNA. He has published more than 100 publications and has a h-index of 50.
Representative Publications:
Peng F, Setyawati MI, Tee JK, Ding X, Wang J, Nga ME, Ho HK, Leong DT. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nature Nanotechnology. 2019, 14, 279–286.
Setyawati MI, Tay CY, Chia SL, Goh SL, Fang W, Neo MJ, Chong HC, Tan SM, Loo SC, Ng KW, Xie JP, Ong CN, Tan NS, Leong DT. TiO2 nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin. Nature Communications. 2013, 4, 1673.
Ding X, Peng F, Jun Z, Gong W, Slaven G, Loh KP, Lim CT, Leong DT. Defect Engineered Bioactive Transition Metals Dichalcogenides Quantum Dots. Nature Communications, 2019, 10, 41.
Setyawati MI, Tay CY, Bay BH, Leong DT. Gold Nanoparticles Induced Endothelial Leakiness Depends On Particle Size And Endothelial Cell Origin. ACS Nano 2017, 11, 5020–5030.
Tay CY, Setyawati MI, Leong DT. Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability. ACS Nano 2017, 11, 2764–2772.
Associate Professor
Department of Chemical and Biomolecular Engineering
National University of Singapore
4 Engineering Drive 4, E5-02-18, Singapore 117585, Singapore
Tel: +65-6516-7262
Email: cheltwd@nus.edu.sg
David Leong is a tenured Associate Professor at the Department of Chemical and Biomolecular Engineering, National University of Singapore. He received his B Chemical Engineering and PhD in biology degrees from National University of Singapore, working on bone tissue engineering with adipose derived stem cells. He did his postdoctoral studies in Howard Hughes Medical Institute, University of Pennsylvania Medical School, working on diabetes and metabolism biological mechanisms. He returned to Singapore to his first independent position as a Lee Kuan Yew Fellow in the Cancer Science Institute, National University of Singapore with a focus on cancer biology. Subsequently, he returned to his alma mater department and was promoted to his current tenured position in 2017. His research interests range from chemical synthesis to biological mechanisms of nanomaterials-biology interactions especially nanoparticles with the endothelium; working with a wide range of materials and constructs, from noble metals nanoclusters to commonly found inorganic nanoparticles to semiconductive transition metals dichalogenides to DNA. He has published more than 100 publications and has a h-index of 50.
Representative Publications:
Peng F, Setyawati MI, Tee JK, Ding X, Wang J, Nga ME, Ho HK, Leong DT. Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness. Nature Nanotechnology. 2019, 14, 279–286.
Setyawati MI, Tay CY, Chia SL, Goh SL, Fang W, Neo MJ, Chong HC, Tan SM, Loo SC, Ng KW, Xie JP, Ong CN, Tan NS, Leong DT. TiO2 nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin. Nature Communications. 2013, 4, 1673.
Ding X, Peng F, Jun Z, Gong W, Slaven G, Loh KP, Lim CT, Leong DT. Defect Engineered Bioactive Transition Metals Dichalcogenides Quantum Dots. Nature Communications, 2019, 10, 41.
Setyawati MI, Tay CY, Bay BH, Leong DT. Gold Nanoparticles Induced Endothelial Leakiness Depends On Particle Size And Endothelial Cell Origin. ACS Nano 2017, 11, 5020–5030.
Tay CY, Setyawati MI, Leong DT. Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability. ACS Nano 2017, 11, 2764–2772.
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