胡育誠教授
Prof. Yu-Chen Hu
Fellow, American Institute for Medical and Biological Engineering (AIMBE)
Distinguished Professor
Department of Chemical Engineering, National Tsing Hua University
Hsinchu, Taiwan.
Biographical Sketch
Dr. Yu-Chen Hu’s research interests include vaccine development, gene therapy, tissue engineering, cancer therapy and synthetic biology. Dr. Hu's lab has developed the enterovirus 71 (EV71) vaccine based on virus-like particle technology and also paves a new avenue to the use of baculovirus as a novel vector for regenerative medicine and cancer therapy. Dr. Hu has also employed burgeoning CRISPR technology and synthetic biology for the metabolic engineering of microorganisms and stem cells for production of bio-derived chemicals and tissue regeneration. Dr. Hu has won the Asia Research Award, Outstanding Research Award (Ministry of Science and Technology, 2006, 2014), BEST Biochemical Engineering Achievement Award, Wu Ta-You Memorial Award, Outstanding Academia-Industry Research Award and Outstanding Young Investigator Award in Taiwan. He is a fellow of American Institute for Medical and Biological Engineering (AIMBE), Program Chair of the Tissue Engineering International & Regenerative Medicine Society-Asia Pacific (TERMIS-AP) 2016 meeting, Conference Chair of Asian Congress of Biotechnology (ACB meeting 2019) and the Vice President of Biotechnology and Biochemical Engineering Society of Taiwan. He currently serves as the associated editor of Current Gene Therapy, deputy editor of Journal of Taiwan Institute of Chemical Engineers, and Coordinator of Chemical Engineering Division, Ministry of Science and Technology.
Recent Publications:
1. Shen, C.-C., Hsu, M.-N., Chang, C.-W., Lin, M.-W., Hu, Y.-C*. 2019 Feb. Synthetic switch to minimize CRISPR off-target effects by self-restricting Cas9 transcription and translation. Nucleic Acids Research. 47: e13 (IF 11.561).
2. Hsu, M.-N., Hu, Y.-C.*. Local magnetic activation of CRISPR. 2019 Feb. Nature Biomedical Engineering. 3: 83-84.
3. Lin, M.-W., Tseng, Y.-W., Shen, C.-C., Hsu, M.-N., Hwu, J.-R., Chang, C.-W., Yeh, C.-J., Chou, M.-Y., Wu, J.-C., Hu, Y.-C.*. 2018, Sep. Synthetic switch-based baculovirus for transgene expression control and selective killing of hepatocellular carcinoma cells. Nucleic Acids Research. 46: e93 (IF 11.561).
4. Hsu, M.-N., Liao, H.-T., Li, K.-C., Chen, H.-H., Yen, T.-C., Makarevich, P., Parfyonova, Y., Hu, Y.-C.*. 2017 Sep. Adipose-derived stem cell sheets functionalized by hybrid baculovirus for prolonged GDNF expression and improved nerve regeneration. Biomaterials. 140: 189-200 (IF 8.806).
5. Lo, S.-C., Li, K.-C., Chang, Y.-H., Hsu, M.-N., Sung, L.-Y., Troung, A.V., Hu, Y.-C*. 2017 April. Enhanced critical-size calvarial bone healing by ASCs engineered with Cre/loxP-based hybrid baculovirus. Biomaterials. 124: 1-11 (IF 8.806).
Fellow, American Institute for Medical and Biological Engineering (AIMBE)
Distinguished Professor
Department of Chemical Engineering, National Tsing Hua University
Hsinchu, Taiwan.
Biographical Sketch
Dr. Yu-Chen Hu’s research interests include vaccine development, gene therapy, tissue engineering, cancer therapy and synthetic biology. Dr. Hu's lab has developed the enterovirus 71 (EV71) vaccine based on virus-like particle technology and also paves a new avenue to the use of baculovirus as a novel vector for regenerative medicine and cancer therapy. Dr. Hu has also employed burgeoning CRISPR technology and synthetic biology for the metabolic engineering of microorganisms and stem cells for production of bio-derived chemicals and tissue regeneration. Dr. Hu has won the Asia Research Award, Outstanding Research Award (Ministry of Science and Technology, 2006, 2014), BEST Biochemical Engineering Achievement Award, Wu Ta-You Memorial Award, Outstanding Academia-Industry Research Award and Outstanding Young Investigator Award in Taiwan. He is a fellow of American Institute for Medical and Biological Engineering (AIMBE), Program Chair of the Tissue Engineering International & Regenerative Medicine Society-Asia Pacific (TERMIS-AP) 2016 meeting, Conference Chair of Asian Congress of Biotechnology (ACB meeting 2019) and the Vice President of Biotechnology and Biochemical Engineering Society of Taiwan. He currently serves as the associated editor of Current Gene Therapy, deputy editor of Journal of Taiwan Institute of Chemical Engineers, and Coordinator of Chemical Engineering Division, Ministry of Science and Technology.
Recent Publications:
1. Shen, C.-C., Hsu, M.-N., Chang, C.-W., Lin, M.-W., Hu, Y.-C*. 2019 Feb. Synthetic switch to minimize CRISPR off-target effects by self-restricting Cas9 transcription and translation. Nucleic Acids Research. 47: e13 (IF 11.561).
2. Hsu, M.-N., Hu, Y.-C.*. Local magnetic activation of CRISPR. 2019 Feb. Nature Biomedical Engineering. 3: 83-84.
3. Lin, M.-W., Tseng, Y.-W., Shen, C.-C., Hsu, M.-N., Hwu, J.-R., Chang, C.-W., Yeh, C.-J., Chou, M.-Y., Wu, J.-C., Hu, Y.-C.*. 2018, Sep. Synthetic switch-based baculovirus for transgene expression control and selective killing of hepatocellular carcinoma cells. Nucleic Acids Research. 46: e93 (IF 11.561).
4. Hsu, M.-N., Liao, H.-T., Li, K.-C., Chen, H.-H., Yen, T.-C., Makarevich, P., Parfyonova, Y., Hu, Y.-C.*. 2017 Sep. Adipose-derived stem cell sheets functionalized by hybrid baculovirus for prolonged GDNF expression and improved nerve regeneration. Biomaterials. 140: 189-200 (IF 8.806).
5. Lo, S.-C., Li, K.-C., Chang, Y.-H., Hsu, M.-N., Sung, L.-Y., Troung, A.V., Hu, Y.-C*. 2017 April. Enhanced critical-size calvarial bone healing by ASCs engineered with Cre/loxP-based hybrid baculovirus. Biomaterials. 124: 1-11 (IF 8.806).
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